![]() In addition, cross-linking with glutaraldehyde vapour will be performed and its influence on long-term biostability has to be analysed. The aim of this study is to develop an electrospinning setup for the fabrication of blood protein based patient-specific scaffolds for cardiovascular applications. A disadvantage of choosing electrospun protein based scaffolds is their high hydrolytic degradation rate in a physiological environment. The biodegradable scaffolds will be gradually replaced by infiltrating and proliferating cells, leading to an effective tissue remodelling. To reduce undesired immune reactions for patients, the use of biopolymer solutions from blood proteins is desirable because proteins contain specific structural and functional information and are biodegradable. Electrospinning is a promising method for the fabrication of biocompatible fine-fibres and porous scaffolds. Therefore, it is important to develop biocompatible scaffolds for cardiovascular applications that have no undesirable effects on the surrounding tissue. ![]() The aim of tissue engineering is a functional tissue replacement by culturing cells on suitable scaffolds. Therefore, the development of a suitable material for the replacement of diseased vascular tissue is desirable. However, the use of such prostheses represents several limitations like activation of foreign body reactions or chronic inflammation. Current therapeutic approaches include alloplastic vascular prostheses (Dacron ®, Teflon ®) to replace or bypass the diseased vessel. With a percentage of 46.2%, these diseases represent the largest cause of total deaths. Worldwide, 17.5 million people died of cardiovascular diseases in 2012.
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